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Amyloid Protein Mediated Neurodegeneration in Alzheimers Disease Alzheimers Disease is a progressive, degenerative disease that affects the mentality. Individuals with AD construe a progressive and specific loss of cognitive adopt resulting from the differentiation of the limbic system, association neocortex, and basal fore header. It is also tended to(p) by the deposition of amyloid in plaques and cerebrovasculature, and the governance of neurofibrillary tangles in neurons. Alois Alzheimer, a German doctor, diagnosed this disease for the first time in 1907. At that time it was considered a r be disorder. Currently, this tragic brain disorder affects approximately four million people; It is the most common type of dementia and the fourth leading trend of death in the United States. Many studies have been do and atomic number 18 still being conducted to determine the exact vitrine of AD. The molecular and biological basis for the degeneration of neurons in AD is incomple tely understood. However, the APP(Amyloid Precursor Protein) and its proteolytic fragments have been implicated to a greater extent often than not and is the focus of most on-going studies. some(prenominal) lines of evidence have strengthened the amyloid hypothesis for Alzheimers Disease. The first being the identification of point mutations with the APP gene in groups of patients afflicted with the familial forms of AD. Second, amyloid deposition temporally precedes the arrangement of neurofibrillary changes. In addition, b-amyloid has been shown to be toxic to neurons. In Alzheimers Disease, b-Amyloid proteins derived from APP are the main component of neuritic plaques. It is believed that errantly processed APP derivatives may induce physiological processes that lead to neurodegeneration and plague formation. Many studies have success widey think APP with AD. One study on transgenic mice with human APP717(associated with familial AD) displayed subcellular neurodegeneration like to those observed in AD, including dy! strophic neurites,...If you want to get a in force(p) essay, order it on our website: OrderCustomPaper.com

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